Nuno Lopes made his professional debut at Teatro da Cornucópia in 1997. In addition to a vast career in theater, it was in cinema that he distinguished himself internationally. He has worked in different languages with directors such as Christophe Honoré, Rebecca Zlotowski, Werner Schroeter, Marco Martins, Valeria Sarmiento, Fanny Ardant, Marcelo Gomes, Céline Devaux, Tiago Guedes, João Canijo, Nicolas Wadimoff, etc.

In his film career, notable works include "Alice" by Marco Martins, "Blood of My Blood" by João Canijo, "Lines of Wellington" by Valeria Sarmiento with John Malkovich, "Sea" by Margarida Gil alongside Maria de Medeiros, "The Great Mystical Circus" by Cacá Diegues with Vincent Cassel, and "An Easy Girl" by Rebecca Zlotowski - winner of the Best French Film award at the Directors' Fortnight of the Cannes Film Festival.

With its world premiere at the 2022 Cannes Film Festival, Nuno portrayed the character of Samuel in "Restos do Vento," a film by Tiago Guedes, and Vitor in "Tout Le Monde Aime Jeanne" by Céline Devaux.

Recently, Nuno participated in the French feature film "Azuro" by Matthieu Rozé (2022) and played one of the main characters in the series "White Lines" by Álex Pina (Netflix) and "Operation Black Tide" (Amazon Prime Videos).

Nuno Lopes has won over 20 national and international awards, including Best Actor at the Venice Film Festival (Orizzonti) and the International Film Festival of Macau with the film "São Jorge" by Marco Martins. He also received the Shooting Star Award at the Berlin International Film Festival for the film "Alice" and has won 5 Portuguese Golden Globes. This year, he won the Sophia Award for Best Supporting Actor with the film "Restos de Vento" by Tiago Guedes.